Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0328

Protein Name

Aquaporin-1

Gene Name

AQY1; AQY1-2; YPR192W; P9677.5

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast)

Length

305 amino acids

AlphaFoldDB

AF-P0CD91-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across membranes. Involved in sporulation; freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains.

Sequence

MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISRDTLRDHFIAAVGEFCGTFMFLWCAYVICNVANHDVALVAAPDGSHPGQLIMIAIGFGFSVMFSIWCFAGVSGGALNPAMSLSLCLARAVSPTRCVVMWVSQIVAGMAAGGAASAMTPGEVLFANSLGLGCSRTRGLFLEMFGTAILCLTVLMTAVEKRETNFMAALPIGISLFIAHVALTAYTGTGVNPARSLGAAVAARYFPHYHWIYWIGTLLGSILAWSVWQLLQILDYTTYVTAEKAASTKEKAQKKGETSSSSAVAEV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/387s103; 10.1534/g3.113.008995; 10.1101/gr.6037607; 10.1074/jbc.273.42.27565; 10.1006/bbrc.1999.0425; 10.1002/1097-0061(200007)16:10<897::aid-yea583>3.0.co;2-t; 10.1074/jbc.m300163200; 10.1073/pnas.0604075103

RefSeq

NP_015518.1